Hematology 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in the platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout Liu et al. J. Biol. Chem. 2020;295:P5307 Read More
Diabetes 12(S)-hydroxyeicosatetraenoic acid is significantly increased in diabetic kidney disease and associated with renal function decline Xu et al. Diabetes Metab. Res. Rev. 2022;e3554 Read More
Other High-fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress Moon et al. Lipid Res. 2021;62:100052 Read More
Other Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration Cloutier et al. PNAS 2018;115:E1550 Read More
Other FcγRIIA expression accelerates nephritis and increases platelet activation in system lupus erythematosus Melki et al. Blood 2020;136:2933 Read More
Other Modulation of gentamicin-induced acute kidney injury by myo-inositol oxygenase via the ROS/ALOX-12/12-HETE/GPR31 signaling pathway Sharma et al. JCI Insight Read More
Other Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA Duchez et al. PNAS 2015;112:E3564 Read More
Other 12-Lipoxygenase as a key pharmacological target in the pathogenesis of diabetic nephropathy Dong et al. Eur. J. Pharmacology 2020;879:173122 Read More
Diabetes 12-Lipoxygenase Products Reduce Insulin Secretion and β-Cell Viability in Human Islets Ma et al. J. Clin. Endocrinol. Metab. 2010;95:887 Read More
Diabetes Role of the 12-lipoxygenase pathway in diabetes pathogenesis and complications Dobrian et al. Pharmacol. Ther. 2019;195:100 Read More
Diabetes Elevated 12-hydroxyeicosatetraenoic acid (12-HETE) levels in serum of individuals with newly diagnosed Type 1 diabetes Hennessy et al. Diabet. Med. 2017;34:292 Read More
Diabetes Expression pattern of 12-lipoxygenase in human islets with type 1 diabetes and type 2 diabetes Grzesik et al. J. Clin. Endocrinol. Metab. 100, E387 Read More
Diabetes 12-Lipoxygenase Inhibitor Improves Functions of Cytokine-Treated Human Islets and Type 2 Diabetic Islets Ma et al. Clin. Endocrinl. Metab. 2017;102:2789 Read More
Diabetes Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes Piñeros et al. Cell Reports 2022;39:13,111011 Read More
Hematology Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice He et al. Science Advances 2020;6:eabd0130 Read More
Hematology Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy Tourdot et al. Trends in Pharmacol. Sci. 2017;38:P1006 Read More
Hematology First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis Adili et al. Arterioscl Throm Vasc Biol. 2017;37:1828 Read More
Hematology Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation Yeung et al. Blood 2014;124:2271 Read More