Hematology 12-LOX catalyzes the oxidation of 2-arachidonoyl-lysolipids in the platelets generating eicosanoid-lysolipids that are attenuated by iPLA2γ knockout Liu et al. J. Biol. Chem. 2020;295:P5307 Read More
Hematology Synthetic high-density lipoproteins loaded with an antiplatelet drug for efficient inhibition of thrombosis in mice He et al. Science Advances 2020;6:eabd0130 Read More
Hematology Targeting 12-Lipoxygenase as a Potential Novel Antiplatelet Therapy Tourdot et al. Trends in Pharmacol. Sci. 2017;38:P1006 Read More
Hematology First Selective 12-LOX Inhibitor, ML355, Impairs Thrombus Formation and Vessel Occlusion In Vivo With Minimal Effects on Hemostasis Adili et al. Arterioscl Throm Vasc Biol. 2017;37:1828 Read More
Hematology Platelet 12-LOX is essential for FcγRIIa-mediated platelet activation Yeung et al. Blood 2014;124:2271 Read More